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US seeks stockpile of safer smallpox vaccine

first_img Acambis and Bavarian Nordic said the Department of Health and Human Services (HHS) has requested proposals to supply the attenuated vaccine called modified vaccinia Ankara, or MVA. Both companies have developed versions of MVA. See also: Peter Wulff, president and CEO of Copenhagen-based Bavarian Nordic, said in a news release, “With this tender, the US government has committed itself to protect the 25% of the population who cannot safely be given current smallpox vaccines. The world market for a safe smallpox vaccine has now been opened, since governmental authorities in the larger European countries will naturally undertake a similar commitment as the American authorities.” Aug 16, 2005 (CIDRAP News) – The US government has called for proposals to supply up to 80 million doses of a weakened smallpox vaccine to protect people for whom the conventional vaccine is too risky, according to two vaccine manufacturers. The vaccine is intended for use in people who face an increased risk of serious reactions to the conventional vaccine, such as children, pregnant women, and people with immune system disorders or eczema. The federal government has stockpiled hundreds of millions of doses of the conventional vaccine over the past few years. The MVA contracts will be funded under Project Bioshield, a program enacted last year to support the development of medical defenses against biological, chemical, and radiological weapons, according to Marc Wolfson, spokesman for the HHS Office of Public Health Emergency Preparedness in Washington DC. Aug 16 Bavarian Nordic news releasehttp://www.bavarian-nordic.com/investor/announcements/2005-29.aspx http://www.cidrap.umn.edu/cidrap/content/bt/smallpox/news/safevax.html Federal officials have set a Sep 29 deadline for receiving company proposals and plan to award one or more contracts in February 2006, according to Acambis and Bavarian Nordic. CIDRAP News stories on previous MVA contracts awarded to Acambis and Bavarian Nordichttp://www.cidrap.umn.edu/cidrap/content/bt/smallpox/news/oct042004smallpox.html Acambis said it launched a phase 2 clinical trial of MVA3000 in 700 healthy adults last month. A phase 1 study yielded good results for safety and immunogenicity, with 97% of subjects who were vaccinated at the highest dose showing antibodies specific to the vaccinia virus, the company said. Existing smallpox vaccines are made with live vaccinia virus, which in rare cases can cause serious or life-threatening side effects such as a severe rash or encephalitis. MVA is a strain of vaccinia that cannot replicate inside human cells and cause a spreading infection, according to HHS. Wolfson said he couldn’t give an estimate of the cost of the MVA vaccine stockpile. But a Reuters report said investment analysts estimated that the full 80 million doses could be worth more than $1.2 billion. The earlier contracts required the companies to test the vaccines in animals, begin clinical trials, and develop plans for mass production. Acambis is collaborating with Baxter Healthcare to manufacture MVA3000. Editor’s note: This story was revised Aug 17 to add information on funding and a link to the government’s request for proposals to supply the vaccine. HHS wants to obtain 20 million doses of MVA within 2 years after awarding a contract and to have an option to buy another 60 million doses in the future, according to a news release from Acambis, based in the United Kingdom. The HHS is also calling for vaccine suppliers to conduct clinical trials and obtain a federal license for their vaccine. Both companies have been developing their versions of MVA under contracts awarded by the National Institute of Allergy and Infectious Diseases in February 2003 and September 2004. Acambis’s vaccine is called MVA3000, and Bavarian Nordic’s is Imvamune.last_img read more

Executive home sells in under a week, setting new suburb record

first_imgThe home at 8 Rigney St, Underwood sold before auctionA DESIGNER home with Versace-inspired pool and an oversized luxury ensuite smashed the sales record for Underwood by $20,000. The home at 8 Rigney St sold after just one week on the market for $1.25 million, well above the suburb median house price of $512,000.Ray White Rochedale selling principal Zishaan Omar said he had 50 group The ensuite is a standout feature of the home.The home has polished timber floors and feature lighting throughout, along with five bedrooms and an open galley-style kitchen that features stone benchtops. Outside there is an entertaining area with outdoor kitchen and a balcony off the second floor living area. The master bedroom has a dedicated make-up area, sitting area, walk-in robe and an ensuite with dual shower, twin basins and freestanding tub. The swimming pool has Versace-inspired tiling.Vendors Anthony and Jung Davie also installed a “glamorous” pool with Versace-inspired tiling after buying the home. Mr Omar said the record sale of 8 Rigney St was a good sign of buyers having confidence in the Underwood market.center_img The home has high end fixtures and fittings.s through the property and received seven offers in the week the home was for sale. More from newsCrowd expected as mega estate goes under the hammer7 Aug 2020Hard work, resourcefulness and $17k bring old Ipswich home back to life20 Apr 2020“The house sold for $1.25 million before auction,” Mr Omar said. “The owners are really stoked and I wish I had more houses like it to sell. The house is certainly lucky No.8.”Mr Omar said potential buyers loved the property from the moment they stepped through its gates. last_img read more

Area Soccer Regional Scores

first_imgArea Soccer Regional Scores.Saturday (10-14)Girls Soccer Regionals.Class 1A @ Forest Park.Vincennes Rivet  2     Oldenburg 1Evansville Mater Dei  3     Providence  0Championship:  Evansville Mater Dei 1-0Class 2A @ New Palestine.Batesville  6     New Palestine  2Bishop Chatard  6     Danville  1Championship:  Bishop Chatard 3-0Class 3A @ Zionsville.East Central  5     Lawrence North  0Guerin Catholic  6     Plainfield  0Championship:  Guerin Catholic 3-0Boys Soccer Regionals.Class 1A @ Providence.South Knox  1     Jac-Cen-Del  0Providence  3     Northeast Dubois  1Championship:  Providence 1-0Class 2A @ Greensburg.Batesville  4     Herron  0Cardinal Ritter  3     Frankfort  1Championship:  Cardinal Ritter 1-0last_img