Tag Archives: 逍遥游江苏信息区

US seeks stockpile of safer smallpox vaccine

first_img Acambis and Bavarian Nordic said the Department of Health and Human Services (HHS) has requested proposals to supply the attenuated vaccine called modified vaccinia Ankara, or MVA. Both companies have developed versions of MVA. See also: Peter Wulff, president and CEO of Copenhagen-based Bavarian Nordic, said in a news release, “With this tender, the US government has committed itself to protect the 25% of the population who cannot safely be given current smallpox vaccines. The world market for a safe smallpox vaccine has now been opened, since governmental authorities in the larger European countries will naturally undertake a similar commitment as the American authorities.” Aug 16, 2005 (CIDRAP News) – The US government has called for proposals to supply up to 80 million doses of a weakened smallpox vaccine to protect people for whom the conventional vaccine is too risky, according to two vaccine manufacturers. The vaccine is intended for use in people who face an increased risk of serious reactions to the conventional vaccine, such as children, pregnant women, and people with immune system disorders or eczema. The federal government has stockpiled hundreds of millions of doses of the conventional vaccine over the past few years. The MVA contracts will be funded under Project Bioshield, a program enacted last year to support the development of medical defenses against biological, chemical, and radiological weapons, according to Marc Wolfson, spokesman for the HHS Office of Public Health Emergency Preparedness in Washington DC. Aug 16 Bavarian Nordic news releasehttp://www.bavarian-nordic.com/investor/announcements/2005-29.aspx http://www.cidrap.umn.edu/cidrap/content/bt/smallpox/news/safevax.html Federal officials have set a Sep 29 deadline for receiving company proposals and plan to award one or more contracts in February 2006, according to Acambis and Bavarian Nordic. CIDRAP News stories on previous MVA contracts awarded to Acambis and Bavarian Nordichttp://www.cidrap.umn.edu/cidrap/content/bt/smallpox/news/oct042004smallpox.html Acambis said it launched a phase 2 clinical trial of MVA3000 in 700 healthy adults last month. A phase 1 study yielded good results for safety and immunogenicity, with 97% of subjects who were vaccinated at the highest dose showing antibodies specific to the vaccinia virus, the company said. Existing smallpox vaccines are made with live vaccinia virus, which in rare cases can cause serious or life-threatening side effects such as a severe rash or encephalitis. MVA is a strain of vaccinia that cannot replicate inside human cells and cause a spreading infection, according to HHS. Wolfson said he couldn’t give an estimate of the cost of the MVA vaccine stockpile. But a Reuters report said investment analysts estimated that the full 80 million doses could be worth more than $1.2 billion. The earlier contracts required the companies to test the vaccines in animals, begin clinical trials, and develop plans for mass production. Acambis is collaborating with Baxter Healthcare to manufacture MVA3000. Editor’s note: This story was revised Aug 17 to add information on funding and a link to the government’s request for proposals to supply the vaccine. HHS wants to obtain 20 million doses of MVA within 2 years after awarding a contract and to have an option to buy another 60 million doses in the future, according to a news release from Acambis, based in the United Kingdom. The HHS is also calling for vaccine suppliers to conduct clinical trials and obtain a federal license for their vaccine. Both companies have been developing their versions of MVA under contracts awarded by the National Institute of Allergy and Infectious Diseases in February 2003 and September 2004. Acambis’s vaccine is called MVA3000, and Bavarian Nordic’s is Imvamune.last_img read more

‘I’m sorry’: Kohli’s impassioned defence of Smith

first_imgINDIA captain labels negative reception for returning Australian Steve Smith   ‘unacceptable’ and called on English crowds to halt booingINDIA captain Virat Kohli  ahs revealed he apologised to Steve Smith on behalf of Indian supporters who booed him at The Oval on Sunday, insisting the former Australia captain doesn’t deserve the reception he’s received during the World Cup.The Indian captain who once suggested friendships with Australian players had been irreparably damaged after a spiteful Test series launched an unlikely and impassioned defence of Smith both during and after his side’s 36-run victory on Sunday.Smith and Kohli are no strangers to one another.The pair most notably clashed during the 2017 Bengaluru Test when Kohli effectively accused Australia of systemic cheating after Smith looked towards his dressing room for help with a review on an lbw decision.  Relations between the two sides have improved substantially and Kohli remains close with several Australian players, including Glenn Maxwell and Marcus Stoinis.Smith has even admitted to adopting elements of Kohli’s subcontinental batting approach into his own game, while the pair caught up during the recent Indian Premier League.“What’s happened has happened like long back, the guy is back, he’s trying to play well for his side,” said Kohli.“Even in the IPL I saw him, it’s not good to see someone down like that, to be honest. “We’ve had issues in the past. We’ve had a few arguments on the field. But you don’t want to see a guy feeling that heat every time he goes out to play.“What’s happened has happened. Everyone has known that. He’s come back. He’s worked hard. He’s playing well for his side now.”The fact Smith had found himself on the boundary at all was itself a rare occurrence.Neither he nor his former vice-captain David Warner have fielded in the deep as both continue to recover from elbow surgery as the pair, who at full fitness rank among Australia’s greatest ever fielders, gradually return to throwing at full capacity.Smith has said the hostile reception from English crowds during the World Cup hasn’t affected him, labelling it “water off a duck’s back” after he made a century in a warm-up game last month.last_img read more